I’ve been an avid user of Instapaper now for quite a while, so I doubt I’ll be using Safari Reader a lot. My workflow goes from GoogleReader (via the web app on my Mac or Reeder on the iPhone) and Twitter for iPhone, to Instapaper. I basically never see the original site any article is published on anymore. No ads. No “surfing” to find content. I choose from headlines that interest me in my Google Reader feed, or links that look interesting from the people I follow on Twitter. I send them all to Instapaper to read later. I read everything as if it were a page of a book. Clean, black text on a white background. No distractions. The Instapaper apps for the iPhone and iPad are world class. The web-based version works perfectly on the Mac or PC.
As long as I’m diligent about finding good RSS feed sources to add to Google Reader, and I continue to follow interesting people on Twitter, I always have tons of great content to read. More than I can handle, usually.
I do think Safari Reader will eventually be obsolete. Instapaper, however, or some service like it, is destined to be the way people access information in the future, as far as I’m concerned. Forget going out to a thousand places to get content. Let the content come to you.
I’ll say it again; the ad-based web is not going to last forever. Figure out some other way to monetize your content.